The increase was due to improved production productivity of the brand new plant partly. Operating expenses. Operating expenses had been RMB97.0 million for the first quarter of 2012, representing an increase of 25.0 percent from RMB77.6 million for the same period in 2011. Analysis and development costs.8 million , or 7.3 percent of net revenues, in comparison to RMB7.8 million , or 6.6 percent of net revenues, for the same period in 2011.FDA regulations allow for the waiver of the NDA submitting fee if the business is filing its 1st NDA and qualifies as a small business with less than 500 employees. The FDA requested the Small Business Administration to determine if AcelRx was your small business, and the SBA ruled that AcelRx cannot qualify as a small business recently.. 14th APS symposium highlights role of endothelin in many biological functions Endothelin is a peptide produced by cells in the arteries and has powerful vessel-constricting effects. Although endothelin is mainly associated with its role in blood pressure control and cardiovascular diseases, it continues to appear in other physiological functions and diseases.