Derdeyn, M.D., Tanya N. Turan, M.D., David Fiorella, M.D., Ph.D., Bethany F. Lane, R.N., L. Scott Janis, Ph.D., Helmi L. Lutsep, M.D., Stanley L. Barnwell, M.D., Ph.D., Michael F. Waters, M.D., Ph.D., Brian L. Hoh, M.D., J. Maurice Hourihane, M.D., Elad I. Levy, M.D., Andrei V. Alexandrov, M.D., Indicate R. Harrigan, M.D., David Chiu, M.D., Richard P. Klucznik, M.D., Joni M. Clark, M.D., Cameron G. McDougall, M.D., Mark D. Johnson, M.D., G. Lee Pride, Jr., M.D., Michel T. Torbey, M.D., M.P.H., Osama O. Zaidat, M.D., Zoran Rumboldt, M.D., and Harry J. Cloft, M.D., Ph.D. For the SAMMPRIS Trial Investigators: Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis Atherosclerotic intracranial arterial stenosis is among the most common causes of stroke worldwide1-6 and is connected with a high threat of recurrent stroke.7-9 Patients with a recently available transient ischemic attack or stroke and severe stenosis are at particularly risky for recurrent stroke in the territory of the stenotic artery despite treatment with aspirin and regular administration of vascular risk factors.8,10 Therefore, substitute therapies are needed for these patients.If parents reported medical seizures, upward adjustment of the dose of study medication was continuing; if no seizures had been reported, up to two 5-minute trials of bedside hyperventilation had been performed. If bedside hyperventilation induced seizures, upward adjustment of the dose was continued; normally, a 1-hour video EEG was obtained. At week 16 , seizure status was determined by method of clinical survey, bedside hyperventilation assessment, and a 1-hour video EEG. At that go to, the presence of clinical or electrographic seizures in subjects who were receiving the best allowable or maximally tolerated dose was considered cure failure; for subjects who have been not receiving the highest allowable or maximally tolerated dosage but were still having seizures, a single additional escalation of the dosage was allowed, and seizure position was reevaluated at a 5th visit four weeks later .