For example, you may begin to absence the essential self-esteem to operate in public places. Many females with the problem often find it hard to be in public places because of fear of embarrassment. This is not surprising considering the fact that bladder leakages may occur without warning. Sometimes a single minute or cough of laughter may be enough to result in a bladder leakage. But, what is the very best solution to this nagging problem? Today There are many treatment methods that are currently available on the market. The medical sector has brought on board several treatment options. It is entirely up to you to choose the method that meets your individual preferences.Murry, M.D., Ph.D., Neal K. Lakdawala, M.D., Carolyn Y. Ho, M.D., Paul J.R. Barton, Ph.D., Stuart A. Cook, M.D., Luisa Mestroni, M.D., J.G. Seidman, Ph.D., and Christine E. Seidman, M.D.: Truncations of Titin Causing Dilated Cardiomyopathy Gene mutation is an important cause of cardiomyopathy. Mutations in eight sarcomere-protein genes trigger hypertrophic cardiomyopathy, detected in 40 to 70 percent of patients.1,2 Variations in more than 40 genes, the majority of which encode components of the sarcomere, the cytoskeleton, or the nuclear lamina, have already been posited or shown to cause dilated cardiomyopathy.3,4 Clinical evaluation identifies 30 to 50 percent of patients with dilated cardiomyopathy as having a relative who is affected or likely to be affected,5-7 implicating a genetic cause.