We used similar solutions to analyze various other secondary outcomes, like the period to an unfavorable result, the status at the final end of treatment, the status at 12 and 18 months among patients with a favorable result at end of treatment, and the position at 18 months relating to a blinded medical review of the data. All patients who received at least one particular dosage of a scholarly study medication were contained in the safety analysis. The proportions of individuals who had at least one grade three or four 4 adverse event were compared across treatment groupings by using the chi-square test. Results Study Patients A total of 2763 patients were screened and 1931 underwent randomization: 909 in South Africa, 376 in India, 212 in Tanzania, 136 in Kenya, 119 in Thailand, 69 in Malaysia, 66 in Zambia, 22 in China, and 22 in Mexico .We included safeguards against potential bias and safeguards against interpretation bias.31 The study also had wide inclusion criteria with a large number of centers in countries with diverse health care systems, in addition to a focus on an end point that is of unequivocal importance to both patients and the health care system. Our study has particular restrictions.9 percent for irrigation pressure and 79.3 percent for irrigation alternative. This degree of adherence is fairly high still, and we discovered a detrimental aftereffect of soap that any intervention crossover would tend to obscure. Our estimates of the treatment effect of high versus low pressure, high versus very low pressure, and low versus very low pressure, although close to 1.0, exclude huge differences but do not exclude small but potentially important differences.