Tag R. Duffy, D.V Click to see more .M., M.P.H., Tai-Ho Chen, M.D., W. Thane Hancock, M.D., M.P.H., Ann M. Powers, Ph.D., Jacob L. Kool, M.D., Ph.D., Robert S. Lanciotti, Ph.D., Moses Pretrick, B.S., Maria Marfel, B.S., Stacey Holzbauer, D.V.M., M.P.H., Christine Dubray, M.D., M.P.H., Laurent Guillaumot, M.S., Anne Griggs, M.P.H., Martin Bel, M.D., Amy J. Lambert, M.S., Janeen Laven, B.S., Olga Kosoy, M.S., Amanda Panella, M.P.H., Brad J. Biggerstaff, Ph.D., Marc Fischer, M.D., M.P.H., and Edward B. Hayes, M.D.: Zika Virus Outbreak on Yap Island, Federated Claims of Micronesia Zika virus is a flavivirus related to West Nile, dengue, and yellow fever viruses.1 Zika virus was isolated in 1947 from a rhesus monkey in the Zika forest near Entebbe, Uganda2; its genome was sequenced in 2006.3 There is serologic evidence of human being Zika virus infection in Asia and Africa, and the virus has been isolated from individuals in Uganda, Nigeria, and Senegal.2-12 Zika virus is believed to be transmitted to humans by infected mosquitoes and has been isolated from Aedes africanus, Aedes luteocephalus, and Aedes aegypti.13-16 No outbreaks and only 14 cases of human Zika virus disease have been previously documented.2,12,17-19 Until this outbreak, no transmission of Zika virus had been reported beyond Africa and Asia.
) The prevalence prices of H2 and H1 had been 0.93 and 0.07, respectively, among whites in this research and 0.35 and 0.37 among blacks. The prevalence prices of H3, H4, and H5 had been 0.22, 0.04, and 0.01, respectively, among blacks. Kogenate and Recombinate , both full-length recombinant aspect VIII products presently approved for use in persons with hemophilia A, match the amino acid sequences of H1 and H2, respectively.21-24 In basic principle, therefore, one in four blacks with hemophilia A who require replacing therapy with recombinant element VIII will receive products that change from their own factor VIII protein at one or two residues, in addition to having amino acid differences attributable to the specific F8 mutation.