– Adverse events included grade 1 nausea, headaches, equilibrium imbalance, dizziness, chest pain, blurred vision, fatigue and high blood pressure. Grade 2 AEs of lightheadedness and decreased sensation in soles and a serious adverse event of confusion in a patient with baseline history of dementia were also observed.. – Reduction in erythropoietin-independent colony formation of up to 39 percent and up to 100 percent in two patients evaluated – relief of constitutional symptoms, including itching, fatigue, back pain and bloating – reducing the number of cells with the JAK2 V617F mutation – Correlation between XL019 exposure and decreases in phosphorylation of STAT, a marker of JAK activity.
Preclinical studies demonstrated that XL019 was well tolerated. Exelixis.
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