Our survey greater than 900 mutations in 111 cancer-associated genes identified only 6 mutated oncogenes, which were present in less than 10 percent of samples. Prognostically significant somatic mutations occurred in patients in every risk groups. Most individuals with EZH2 or ASXL1 mutations experienced low or intermediate-1 risk based on the IPSS . The presence of EZH2 mutations was highly associated with decreased general survival in the stepwise, multivariable model that regarded age, sexual intercourse, IPSS risk group, and the presence of various other mutations .Once the acne is completely treated the natural pimples treatment can be continued to keep the problem from returning without the side effects. Laser acne treatment: Laser acne treatment is among the mostly followed acne medicine in the present era for the reason of it being an acne medicine that produces a more lasting effect in comparison with the other many pimples medications. Laser acne treatment may be the most popular & most commonly followed acne medication due to one cause that the results are phenomenal and the other being the fact that the laser beam machines being produced across the world in large quantities the costs too have reduced as mentioned by few Israeli pimples sites.